Endosomal sorting complexes required for transport lock shock and barrel art proteins (ESCRT) catalyze the fission of cellular membranes during budding of membrane away from the cytosol.Here we have used Total Internal Reflection Fluorescence (TIRF) microscopy to visualize the recruitment of ESCRTs specifically, ALIX, CHMP4b and VPS4 onto the buddi
Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures.As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures.We have created a pipeline that combines high-throughput screening in zebrafish with subsequent validation in two mammalia
Peripheral Nerve Blocks (PNBs) are widely used for postoperative pain management.PNBs can improve postoperative recovery time and decrease the use of opiates after surgery.PNBs with Local Anaesthetics (LAs) alone here last only a few hours.Adjuvants are medications that can be added to LAs to prolong the duration of PNBs.Dexmedetomidine (DEX) is me
Risk aversion in game theory is usually modeled using expected utility, which was criticized early on, leading to an teal horse blanket extensive literature on generalized expected utility.In this paper we are the first to apply μ–σ theory to the analysis of (static) games.μ–σ theory is widely accepted in the finance literature; using it al
Jawi is the invertatop squeeze bottle earliest writing script of the Malay Archipelago that was derived from Arabic letters.Old Malay Jawi manuscripts may provide vital information about the legacy, cultures, and historical evolution of the Malay Archipelago over time.However, while preserved, old Malay Jawi manuscripts tend to be damaged.Image inp